Likewise, I have to think that Carson Daly doesn't mean to say, "Your wife has cheated on you and given you the horns of a cuckold," to all those MTV viewers who watch him faithfully when he makes "horn hands." MTV has such a large audience, and so many wives to corrupt, that I have to give him the benefit of the doubt here, despite his reputation as a ladies' man.
More likely, he's using the "hang loose" meaning, or possibly even the American Sign Language gesture that means, "I love you" (and have no intention of trying to seduce your wife).
Nonetheless, in many parts of the world and depending on how the horn fingers are pointing, the gesture is quite an insult, ranging from the wife slur to a more generic curse upon you.
Similarly, George Bush, Sr., did not mean to say, "Up yours!" to Australians when he visited there in the early '90s, but when he flashed the victory sign, he pointed his palm in the wrong direction and accidentally made the news that way. It's an honest mistake among conservatives, apparently. Margaret Thatcher did it too and the Associated Press caught it on film.
Even the "thumbs up" gesture Bill Clinton often employed during his presidential speeches is offensive to some. In Greece and Sardinia, it means something that can only be politely said to one of the local olives: Get stuffed.